Patients enrolled at 57 emergency departments across the USĪ Word on Response-Adaptive Comparative-Effectiveness Trial Design:.Compared efficacy and safety of 3 IV anticonvulsive agents: levetiracetam, fosphenytoin, and valproate in benzodiazepine refractory patients.Multicenter, randomized, blinded, comparative effectiveness trial.Established Status Epilepticus Treatment Trial (ESETT).Also Be Sure to Checkout our YouTube Channel From Research to Practice Episode 3.0 – The ESETT Trial Despite recent pediatric studies (ConSEPT, ECLIPSE etc) there is limited guidance on the efficacy or safety of second line mediations for status epilepticus. Thus, prompt termination of seizure activity with second line agents is critical. The longer the seizure continues, the more likely patients can have cardiac/respiratory complications, brain injury, rhabdomyolysis, hyperkalemia, and acidosis. One of the key aspects of management of status epilepticus is early termination. ![]() Levetiracetam, fosphenytoin, and valproate). ![]() The choice of second line medication has been hotly debated (i.e. While most seizure activity responds to appropriately dosed benzodiazipines, some will not respond. Background: Dealing with a patient in status epilepticus, refractory to treatment with benzodiazepines, can be a sphincter tightening ordeal.
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